HEART SOUNDS CHARACTERISTICS FROM A 3D ACCELEROMETER IN HEART FAILURE PATIENTS

BackgroundHeart sounds (HS) are an important cardiac hemodynamic marker. The capability of a miniaturized three-dimensional (3D) accelerometer (AXL) present in implantable electronic devices (CIED) to detect HS clinical setting, especially heart failure (HF) patients (pts), has not been performed yet.ObjectiveThe objective this investigation was assess the feasibility measuring from 3D AXL on pts hospitalized due acute HF decompensation. characteristics were compared against those healthy subjects.MethodsData collected with custom wearable data collection unit (DCU) which included sensor capable x/y/z axis recording HS, electrodes for simultaneous electrocardiogram (ECG) collection, and removable memory storage. DCU placed chest decompensation or volunteers 48 hours . amplitude electromechanical activation time (EMAT), defined as interval between QRS S1, measured one hour ensemble averaged recorded beats.ResultsEleven NYHA class III-IV (10 male, median age 59 years, EF 20%) 5 subjects (2 42 years) analysis. Overall, features S1 S2 detectable x-axis z-axis all 16 subjects. demonstrated be axis-dependent, highest (17.3±4.8 mG). In subject audible S3, S3 also detected (4.9±0.9 Between groups, statistically different mG vs. 20.6±9.6 mG, p=0.43, figure 1A) while EMAT significantly longer (78.5±26.2 msec 47.4±9.5 msec, p=0.005, 1B).Conclusions yet. Heart ObjectiveThe MethodsData beats. Data ResultsEleven 1B). Eleven Conclusions